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1.
Journal of Basic and Clinical Pharmacy ; 11(3):1-1, 2020.
Article in English | CAB Abstracts | ID: covidwho-2012258

ABSTRACT

This study provides a simple, widely available deterrence medication to minimize COVID-19 infection using by tea and coffee infusions. By mixing white with an equal amount of water, add a small amount of tea/coffee infusion. Dull brownish albumen-tannin complex, a soft precipitate is formed and sinks to the bottom. The infusion should reach the furthest points in the respiratory tract so that a maximum number of viral particles are trapped. It is necessary to hold the infusion rolling about for a little while, 20 seconds in the mouth before swallowing. Gargling with the infusion is better. Tannins in tea or coffee infusions will form complexes with the 4-5 types of viral surface proteins [spikes], rendering them ineffective. Protein-tannin astringent complexation is a fundamental chemical reaction and is bound to act, unlike specific antimetabolites or enzyme-mediated actions of antibiotics. In fact, tannins react to some extent with the cell lining of the mucous membranes of the mouth and stomach. Tannins also chelate iron [Fe] and other metal ions required for many of the metabolic reactions of micro-organisms [viruses?], depriving them of these nutrients and further retarding their propagation. Two gargles per day, 12 hours apart, are recommended to disable the virus and eventually kill it. The procedure disables free viruses before tissue invasion. Therefore, the earlier the gargle commences, the better. Suspected contacts should preferably have three daily eight-hourly gargles. Astringent activity is an added activity of tea and coffee, demonstrated in this study [using E. coli and Salmonella] to that of immune boosting action generally spoken about.

2.
Journal of Basic and Clinical Pharmacy ; 11(3):2-2, 2020.
Article in English | CAB Abstracts | ID: covidwho-2012257

ABSTRACT

This editorial provides a brief information on how the coronavirus initially enters into the central nervous system (CNS) via the synaptic route followed by first capturing the Peripheral nerves, where trans-synaptic transfer in avian bronchitis and HEV67 virus. It has been observed in the study that SARS-CoV possess ananalogous potential with SARS-CoV-2, and both are highly similar. The mechanism about the entry of coronavirus into the nose, invade in CNS through olfactory bulb while nasal infection which leads to cause demyelination and inflammation, Further it reaches to the whole brain via Barrier of Blood-Brain and CSF via Blood-CSF barrier within 7 days which leads to respiratory disease due to the inability of air into the lungs as the defects in respiration controlled by the nervous systemand patients show symptoms like neurologic signs. According to theepidemiology study, the first symptom is dyspnoea which shows within 5 days, followed by admission in hospital at 7 days and intensive care at 8 days for SARS-CoV-2 and this latency period is sufficient for the virus to enter into CNS and destroy the medullary neurons which further causes respiratory problems.

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